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Our Top 5 Berberine Supplements of 2025

Find out which supplements actually work and which to stay away from

Advertising Disclaimer This website is supported by its audience. The content is not a news article or independent review. We compare and rank products and may include affiliate links. This comparison and ranking has been sponsored by Bettervits. For more information, see Advertising Disclosure. This website is supported by its audience. The content is not a news article or independent review but is a sponsored comparison by Bettervits.

What Is Berberine?

Berberine has been used medicinally for over 3000 years due to its robust health and heart benefits. As a bioactive compound found in plants, this powerful ingredient has been shown to positively impact blood sugar levels, blood pressure, weight loss and heart health.

A good quality Berberine supplement could greatly help with promoting a healthier heart, weight loss and may be beneficial for those with diabetes. However, not all Berberine supplements are equal and choosing the wrong kind can be an ineffective, costly mistake.

We’ve listed below the benefits, what to look for and compared 5 leading products

Benefits of High Quality Berberine

Berberine Supplements can be a very effective and inexpensive way to boost your heart health. By choosing the right supplement, you may see an improvement from just 3-4 weeks.

  • Balances Blood Sugar Levels

  • Boosts Heart Health

  • Lowers Glucose Levels

  • Helps Balance Blood Pressure

  • Supports Healthy Weight Loss

  • Supports Healthy Cholesterol

What To Look For?

Berberine Supplements are NOT all the same. It’s important to choose quality, proven formulas from trusted brands to see real benefits.

  • At Least 650mg of Berberine Per Serving Choose a supplement that includes at least 650mg, with 650mg being the optimal dosage of Berberine. This dosage amount has been cited in multiple studies.
  • US Made It is important to look for a product which is manufactured in the US. This helps to ensure that the product ingredients are accurate and follow good manufacturing practices based on US regulations.
  • Money-Back Guarantee Companies that stand by their product with a 60 day money back guarantee tend to have higher quality products. They also give you sufficient time to see results or return the product.

What Should I Avoid?

  • Poor Formulations & Doses It is recommended to stay away from products which do not contain pure Berberine. While some supplements may include a complex of ingredients, it is best to look for pure Berberine supplements that come from natural sources such as Berberis Astrata.
  • Artificial Reviews Watch out for product listings on Amazon and other marketplaces. In many cases, these reviews are fake and only made to increase their visibility. Buy from brands that have trusted-looking websites and produce their supplements locally.

1. Berberine [ 1 ]

by Bettervits

A+

OVERALL GRADE

TOTAL RANKING

  • Ingredient Safety
    9.9AVG. 9.9/10
  • Projected Efectiveness
    9.8AVG. 9.8/10
  • Value
    9.7AVG. 9.7/10
  • Return Policy
    9.5AVG. 9.5/10
  • Customer Satisfaction
    9.6AVG. 9.6/10

Pros

  • 1,000mg of Pure Berberine
  • Sourced From “Berberis Astrata”
  • Vegan Friendly
  • Made in USA with US & Global Ingredients
  • Free Shipping
  • 60 Day Money Back Guarantee

Cons

  • Only Available Online Only Available Online
  • Sometimes Out of Stock

The Bottom Line

Out of all the Berberine supplements we have reviewed in-house - Bettervits came out on top in almost every benchmark.

Firstly, this formula contains a potent 1,000mg serving of Berberine, which is one of the highest in the US market. This is also the clinically studied dose which has shown material health benefits.

Moreover, they use purely sourced Berberine from “Berberis Astrata”, a type of plant which contains Berberine.

In addition, Bettervits is fast becoming one of the biggest names when it comes nutrition in the USA. Their products are Made in USA using local & global ingredients. Most importantly, all their products are backed by a 60 day money back guarantee, so readers can be assured of their quality and try them risk free. *

* Results and rankings are based on subjective opinion and do not necessarily reflect typical results from the use of these products. Please visit product website for more information.
We found one coupon code for this product: PRO10 for 10% off
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2. Berberine

by Klaire Labs

B+

OVERALL GRADE

TOTAL RANKING

  • Ingredient Safety
    9.2AVG. 9.2/10
  • Projected Efectiveness
    9.0AVG. 9.0/10
  • Value
    9.1AVG. 9.1/10
  • Return Policy
    9.5AVG. 9.5/10
  • Customer Satisfaction
    8.8AVG. 8.8/10

Pros

  • Vegan Friendly
  • Capsule Form

Cons

  • Low 500mg Dose
  • Expensive
  • No Money Back Guarantee

The Bottom Line

This Berberine formula comes with a 500mg dose over a 2 capsule serving size. They source their Berberine from the Amur cork tree and it contains no other ingredients. However, this formula doe include fillers, such as Stearic Acid.

We generally recommend using a clean-as-possible formula, free from fillers or other agents. In addition, 500mg dose is lower than some other competing products on the market.

Lastly, this product is one of the pricier options on the market which impacts the value for money given the lower dosage.*

* Results and rankings are based on subjective opinion and do not necessarily reflect typical results from the use of these products. Please visit product website for more information.
We found one coupon code for this product: PRO10 for 10% off
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3. Berberine

by Allergy Research Group

C

OVERALL GRADE

TOTAL RANKING

  • Ingredient Safety
    8.7AVG. 8.7/10
  • Projected Efectiveness
    89AVG. 8.9/10
  • Value
    9.0AVG. 9.0/10
  • Return Policy
    8.2AVG. 8.2/10
  • Customer Satisfaction
    8.6AVG. 8.6/10

Pros

  • Vegetarian Friendly
  • Capsule Form

Cons

  • Only 500mg Per Serving
  • Pricey
  • No Money Back Guarantee On Opened Bottles

The Bottom Line

Allergy Research Group is a renowned name in the nutrition space and has been around for a long time. Their Berberine formula contains 500mg per serving of Berberine HCl.

They source their Berberine from Indian Barberry. We could not find whether this product contained any fillers.

Overall it is a good quality formula but the potency of the product is less than some competing products which are advertised for cheaper.*

* Results and rankings are based on subjective opinion and do not necessarily reflect typical results from the use of these products. Please visit product website for more information.
We found one coupon code for this product: PRO10 for 10% off
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4. Berberine

by Good State

D

OVERALL GRADE

TOTAL RANKING

  • Ingredient Safety
    8.5AVG. 8.5/10
  • Projected Efectiveness
    8.0AVG. 8.0/10
  • Value
    8.1AVG. 8.1/10
  • Return Policy
    8.0AVG. 8.0/10
  • Customer Satisfaction
    8.4AVG. 8.4/10

Pros

  • Vegetarian Capsule
  • No Fillers
  • Made in USA From Global Ingredients

Cons

  • Small 400mg Dose
  • No Money Back Guarantee

The Bottom Line

This Berberine formula by Good State is an affordable option with a much lower dose than competing products. With just 400mg of Berberine per serving, it is less than the expertrecommended dose for many people.

In addition, it does not specify where the Berberine is sourced from, which is normally good to know for the sake of transparency.

While they do have a satisfaction guarantee, it is not clear whether this permits you to try the product and return if it you do not see improvements.*

* Results and rankings are based on subjective opinion and do not necessarily reflect typical results from the use of these products. Please visit product website for more information.
We found one coupon code for this product: PRO10 for 10% off
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5. Berberine

by Ambrosial

D-

OVERALL GRADE

TOTAL RANKING

  • Ingredient Safety
    8.5AVG. 8.5/10
  • Projected Efectiveness
    7.6AVG. 7.6/10
  • Value
    7.3AVG. 7.3/10
  • Return Policy
    8.1AVG. 8.1/10
  • Customer Satisfaction
    8.2AVG. 8.2/10

Pros

  • 500mg of Berberine
  • Vegan Friendly

Cons

  • Low Potency of 500mg
  • Made in India
  • Does Not Mention Source of Berberine
  • No Money Back Guarantee

The Bottom Line

Ambrosial’s Berberine product comes in last due to a few cons. Firstly, it is made in India and therefore may not follow US manufacturing best practices. With little manufacturing oversight, there is a risk of having inaccurate ingredients or counterfeit products.

In addition, while it contains a reasonable dose of 500mg, slightly below the recommended 650mg, it does not specify where the Berberine is sourced from.

Lastly, the company does not offer a money back guarantee, which could mean customers may be out of pocket should they not see the desired effect.

* Results and rankings are based on subjective opinion and do not necessarily reflect typical results from the use of these products. Please visit product website for more information.
We found one coupon code for this product: PRO10 for 10% off
LEARN MORE

2025's Top Berberine Supplement

Overall, we highly recommend Bettervits Berberine and have chosen it as #1 based on a strict, scientific review of it's ingredients, formula, doses as well as the brand's ethics and customer satisfaction.

MADE
IN THE USA

FREE
SHIPPING

MONEY-BACK
Guarantee

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Final Thoughts

Berberine is a popular product that is used worldwide. However, as with all supplements, it's important to do your research to ensure you are only using those with the highest chance of success. We conduct in-depth reviews to help our readers avoid common pitfalls associated with supplements, allowing you to shop smart and safely.

After thorough research across hundreds of brands, it's clear that Bettervits offers an all-round 5 star product, with effective ingredients, robust formulas and a thoughtfulness for customer satisfaction. This makes it, in our opinion, the best Berberine supplement on the market.

Lastly, Bettervits provides a 60 day money back guarantee if you're not 100% satisfied.

CLICK HERE TO TRY BETTERVITS BERBERINE

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We strive to ensure that comparisons are made on the basis of factual information such as ingredients, quantity of ingredients, real customer testimonials, manufacturing location, return policies and other pertinent information to evaluate a product.

The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a health care provider. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any diseases or medical conditions.

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